NEUTROPHILIC RIBONUCLEIC ACID EXPRESSION AS A CLINICAL TOOL IN DETECTING CEREBRAL ANEURYSMS
December 14, 2018 / Original Source
Intracranial aneurysms (IAs) can have catastrophic consequences when they rupture. Despite their potentially fatal nature, nearly 6% of the American population unknowingly lives with IAs. The current gold standard for detecting IAs is digital subtraction angiography (DSA). An inexpensive and sensitive blood test screening method for IAs would prove useful given the cost ineffectiveness and risks of DSA. Previous studies have shown persistent inflammation with neutrophilic response in aneurysmal endothelium, making neutrophils a potential screening target for IAs. Given the inflammatory microenvironment of cerebral aneurysms and the previously found connection between RNA expression and vascular disease, Tutino et al. hypothesized that circulating neutrophils carry a unique transcriptional signature of IAs.
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Full Reference:
Neutrophilic Ribonucleic Acid Expression as a Clinical Tool in Detecting Cerebral Aneurysms
Michael P D’Angelo, BS, Kamil W Nowicki, MD, PhD, Guy Beresteanu, Raymond F Sekula, Jr, MD, MBA. Neurosurgery 84(1): pg.E17-E19. https://doi.org/10.1093/neuros/nyy510
